ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation.

Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.

Recent data indicate that the proinflammatory cytokine, interleukin (IL)-17, stimulates certain effector functions of human macrophages. We evaluated whether IL-17 mediates allergen-induced accumulation of airway macrophages and, if so, whether such an effect relates to the control of macrophage recruitment and survival. BALB/c mice were sensitized and challenged with ovalbumin. Three hours bef...

Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

RATIONALE In a guinea pig model of allergic asthma, using perfused tracheal preparations ex vivo, we demonstrated that L-arginine limitation due to increased arginase activity underlies a deficiency of bronchodilating nitric oxide (NO) and airway hyperresponsiveness (AHR) after the allergen-induced early and late asthmatic reaction. OBJECTIVES Using the same animal model, we investigated the ...

Allergen-induced airway inflammation and its therapeutic intervention

Allergen inhalation challenge has been useful for examining the mechanisms of allergen-induced airway inflammation and the associated physiological changes and for documenting the efficacy of drugs to treat asthma. Allergen inhalation by a sensitized subject results in acute bronchoconstriction, beginning within 15-30 min and lasting 1-3 hr, which can be followed by the development of a late as...

Airway Inflammation Results in Enhanced Allergen-Induced Matrix Metalloproteinase-9 Deficiency

Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma.

RATIONALE The tachykinins substance P and neurokinin A (NKA) are implicated in the pathophysiology of asthma. OBJECTIVE We tested the safety, tolerability, and pharmacologic and biological efficacy of a tachykinin NK(1)/NK(2) receptor antagonist, AVE5883, in patients with asthma in two double-blind, placebo-controlled crossover studies. METHODS The pharmacologic efficacy of a single inhaled...